Amy, here's a brand new study abstract for you to check out. Note that while the results achieved only "near-significance," the authors seem to feel that the effect was large enough to note in the Conclusion. Statistical significance is a technical term, and non-significance doesn't always mean what it sounds like. Also, it doesn't say what form the calcium or D were in. My sense is that the D was D3, given the dosage. D also appears to be the important nutrient here.
Firouzabadi, R.D., Aflatoonian, A., Modarresi, S., Sekhavat, L., and Taheri, S.M. (2012, May). Therapeutic effects of calcium & vitamin D supplementation in women with PCOS [Abstract]. Complementary Therapies in Clinical Practice, 18(2):85-88. DOI:10.1016/j.ctcp.2012.01.005
To evaluate the efficacy of calcium & vitamin D supplementation in infertile women suffering from polycystic ovary syndrome (PCOS), and to assess levels of 25-hydroxy vitamin D in these patients.
In a case control study, 100 infertile PCOS women based on a randomly divided into two groups. Group I (n = 50) were treated with metformin 1500 mg/day, and group II (n = 50) treated with metformin 1500 mg/day plus Calcium 1000 mg/day and Vitamin D 100000 IU/month for 6 months. Patients were followed by transvaginal sonography at first, 3 and 6 months later for evaluating dominant follicle.
BMI, menstrual regularity, follicle diameter, pregnancy, serum 25-OH-vitamin D level were matured and compared in two groups.
BMI decreased almost significantly (25.49 ± 1.88 vs 26.28 ± 2.15, p: 0.054) in group II. A better improvement was gained in regulating menstrual abnormalities (70% vs 58%, p: 0.211), follicle maturation (28% vs 22%, p: 0.698), and infertility (18% vs 12%, p: 0.401) in group II compared with group I, but these results were not statistically significant. Eighty three percent of all the PCOS patients showed vitamin D deficiency while 35% were severely deficient. The serum 25-OH-vitamin D mean levels were 13.38 ± 6.48 ng/ml. Vitamin D deficiency was recompensed in 74% of the PCOS patients who had taken calcium & vitamin D supplementation. There was no correlation between BMI and 25-OH-VD before and after the treatment (p ≥ 0.01).
This study showed the positive effects of calcium & vitamin D supplementation on weight loss, follicle maturation, menstrual regularity, and improvement of hyperandrogenism, in infertile women with PCOS.